Founder Mutation Genotyping and Sudden Cardiac Arrest

Founder Mutation Genotyping and Sudden Cardiac Arrest

After the Human Genome Project, a resulting explosion of genetic information has led to the identification of thousands of new disease-susceptibility genes. This has created the dream of genetic medicine, or so-called precision medicine, where the identification of pathogenic mutations would lead to the early diagnosis, treatment, and prevention of disease. This ideal has no more important impl...

Sudden Cardiac Arrest

Sudden cardiac arrest during sports.

Exercise can trigger an acute cardiac event which may precipitate sudden cardiac arrest (SCA). On the other hand, exercise is important for physical fitness and prevention of cardiovascular disease, and the medical community should therefore inform the general public of the health benefits of sports and exercise. At the same time, the public are exposed to alarmist mass media coverage of athlet...

Sudden cardiac arrest and automated external defibrillators.

major (approximately 66–94.5%) cause of sudden death worldwide.1–4 The remaining causes of sudden death are noncardiac conditions, including epilepsy, alcohol abuse, pulmonary embolism, trauma, cerebrovascular accidents and unknown etiology.5 The annual occurrence of sudden death is 350,000–450,000 in the United States, 10.5 per 100,000 population in United Kingdom and 37 per 100,000 in Japan. ...

Population movement and sudden cardiac arrest location.

BACKGROUND Although the benefits of automatic external defibrillators are undeniable, their effectiveness could be dramatically improved. One of the key issues is the disparity between the locations of automatic external defibrillators and sudden cardiac arrests (SCAs). METHODS AND RESULTS From emergency medical services and other Parisian agencies, data on all SCAs occurring in public places...